New Colgate Total®: Whole Mouth Health and the role of dental biofilm. The next generation toothpaste, a clinically proven step forward in the quest for Whole Mouth Health. Decades of research have led to the development of a patented formulation for new Colgate Total®. This advanced toothpaste helps achieve Whole Mouth Health with a new technology that works with dual zinc plus arginine to provide proactive protection to the whole mouth, and help prevent the most relevant oral diseases and conditions. The formulation of dual zinc plus arginine effectively controls biofilm. Clinically proven whole mouth antimicrobial protection.